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Controlling Ni redox states by dynamic ligand exchange for electroreductive Csp3–Csp2 coupling

ELECTROREDUCTIVE CSP3–CSP2 COUPLING

This case study was reported in Controlling Ni redox states by dynamic ligand exchange for electroreductive Csp3–Csp2 coupling | Science C. S. Sevov et al., Science. 2022, 376, 410

Cross-electrophile coupling of aryl and alkyl electrophiles rely on the merger of an electrochemically active complex that selectively reacts through 1e– processes and an electrochemically inactive Ni0(phosphine) complex that selectively reacts with aryl electrophiles through 2e– processes. Accessing Ni0(phosphine) intermediates is the key challenge.

DISCOVERY OF A NOVEL PATHWAY FOR ELECTROCHEMICAL GENERATION AND APPLICATION IN ALKYLATION REACTIONS

The authors uncover a previously unknown pathway for electrochemically generating these key complexes at mild potentials through a choreographed series of ligand-exchange reactions. The mild methodology is applied to the alkylation of a range of substrates including natural products and pharmaceuticals.